Hematology-Oncology · Physical Diagnosis PDX

Amyloidosis

3 patients · 4 clips

A condition in which abnormal proteins are deposited throughout the tissues of the body. Characteristic physical findings include macroglossia, enlarged shoulders (shoulder pad sign), and purpura (including racoon eyes).

Cutaneous T-cell Lymphoma

1 patients · 3 clips

T cell lymphomas that involve the skin, manifest with a variety of skin lesions. Hematology Oncology Patient 1: This patient is an old-aged man admitted with red nodular rash, who was diagnosed on biopsy to have cutaneou

Leser-Trelat sign

1 patients · 2 clips

Characterized by the sudden development of multiple seborrheic keratoses, associated with an underlying malignancy. Hematology Oncology Patient 1: This patient has

Pallor

1 patients · 2 clips

Pale color of the mucous membranes and skin—particularly in locations where vessels are close to the surface (eg, palmar creases and nail beds). Hematology Oncology Patient 1: This is a young man who developed acute seve

Petechial Rash

1 patients · 4 clips

Petechiae and purpura are the result of extravasation of blood from the vasculature into the skin or mucosa, usually occurring in the dependent regions of the body. Petechiae are pinpoint hemorrhages ≤2 mm in size, purpu

Purpura fulminans

2 patients · 6 clips

A thrombotic disorder that occurs as a result of congenital or acquired protein C deficiency, often caused by sepsis, particularly involving certain organisms (eg, Neisseria meningitidis). Hematology Oncology Patient 1:

Radiation Tattoos

2 patients · 2 clips

The presence of tattoo markers on the skin can be a helpful clue to previous external beam radiation therapy. Look for blue macules that are around 2-4 mm in size. Hematology Oncology Patient 1: This is a middle-aged man

Sweet’s Syndrome

1 patients · 1 clips

One of the neutrophilic dermatoses, Sweet’s syndrome can be idiopathic, malignancy-associated, and drug-induced. It presents with tender erythematous skin lesions in the form of papules, nodules, and/or plaques. Hematolo

Paroxysmal Nocturnal Hemoglobinuria

1 patients · 1 clips

Characterized by the sudden development of multiple seborrheic keratoses, associated with an underlying malignancy. Inherited loss of RBC anchor proteins leading to complement-mediated intravascular hemolysis. Often trig

Breast Carcinoma

1 patients · 1 clips

Usually manifests as a palpable and/or visible mass in the breast. A particular subtype, called inflammatory breast cancer, presents with breast swelling and thickening and hardening of the skin overlying the lesion rese

Virchow’s Node

1 patients · 2 clips

Patient 1: This is a middle-aged man with an extensive smoking history who presented with dysphagia and hyponatremia, and was found to have supraclavicular lymphadenopathy (Virchow’s node). Biopsy demonstrated small cell